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examined the effectiveness of a Japanese oral supplement containing collagen peptides on skin hydration and the natural moisturizing factor content in 99 healthy Japanese women, aged 3550 years, who were divided into three groups (33 subjects/group) and received 1 or 5 g of collagen peptides or placebo once daily for 12 weeks [38]

Your skin may be filled with bumps, feel rough to the touch, or get irritated easily after shaving

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Lancet Glob Health 5(12):e1221e1234 Das S et al (2022) Innate immunity dysregulation in aging eye and therapeutic interventions

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This approach is particularly valuable in long-term protocols exceeding 8-12 weeks where continuous single-compound administration might produce diminishing returns through tolerance development