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185,194,195 The interaction of BAs and intracellular FXR not only inversely regulates BA synthesis, but inhibits hepatic adipogenesis and steatosis, reduces hepatic gluconeogenesis, and increases peripheral insulin sensitivity through transcription of GLUT4

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In the metabolic formation, Hcy-thiolactone spontaneously reacts with protein lysine residues 12,13,16 and generates N-Hcy-protein

Subsequent in vivo work in transected tendon and ligament models has reproduced these findings and added documentation of accelerated collagen deposition, growth-hormone receptor upregulation, and improved biomechanical recovery markers