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Biochimica et biophysica acta , 1830 (5), 31433153

The common thread is that isotretinoin's metabolic footprint is wide, and the liver has limited reserve capacity to handle multiple concurrent stressors at typical therapeutic doses

doi: 10.1093/bib/bbae350

Guidelines and recent meta-analyses note the biological promise but still rate the inositol evidence as low-to-moderate because dosing, phenotyping, and endpoints vary widely

After harvesting, cells were plated to a density of 6 0.5 10 5 cells/mL in six-well plates (Corning) and allowed to incubate for 72 h at 37C in a 5% (v/v) CO 2 atmosphere to a confluence of 90%

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