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doi: 10.1093/humrep/dev219 75 AgarwalASalehRA

Possible process of compromised immunotolerance in women is asymmetrical X chromosome inactivation (XCI), which cause evade from the presentation of X-linked self-antigens in the thymus and following deterioration of T cell tolerance

Trigeminal Neuralgia, aka the 'suicide disease,' causes excruciating facial pain

In RP genetic mutations lead to death of rod photoreceptors, and as a significant number of rods is lost, then cones begin to degenerate 2

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Finally, while our groups were matched for age, the sex imbalance (higher female proportion in migraine) reflects epidemiology but could introduce confounding