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Overall, scientific efforts over the past twenty years have shed light on the behavior of meningococcus within the host cell and have supported a model in which, after internalization by the host cell, the meningococcus is able to avoid lysosomal killing by cleaving LAMP1 through IgA protease, and to escape from the internalization vacuole through the C-terminal hemolytic domain of HrpA, reaching the cell cytosol

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