doi: 10.3390/ijms24010449 77 DaherRManceauHKarimZ
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Yuan Y, Zhai Y, Chen J et al (2021) Kaempferol ameliorates oxygen-glucose deprivation/reoxygenation-induced neuronal ferroptosis by activating Nrf2/SLC7A11/GPX4 axis
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In this context, one could assume that degradation of chondroitin sulfate proteoglycans in melatonintreated nerves (Krityakiarana et al., 2016) could depend on activation of the proteases with melatonin, in contrast to other tissue types where melatonin inhibits the MMPs
Thymalin and Epithalamin's synergistic effects further emphasise their geroprotective potential, especially as pineal peptides have been observed to protect the thymus from age-related degeneration through immunoendocrine cooperation and transcription activation