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Quantification was performed by peak area ratios of cagrilintide versus internal standard

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doi: 10.1007/s11934-020-01023-9 108 BettocchiCPalumboFSpilotrosMLucarelliGPalazzoSBattagliaMet al

Based on available Phase 2 data, both agents share a side-effect profile broadly consistent with other medicines acting on metabolic hormone pathways, though the triple-agonist mechanism of retatrutide introduces some additional considerations

Tachyphylaxis There are anecdotal reports suggesting tachyphylaxis, or loss of efficacy, of TCS over time, necessitating higher doses or more frequent applications [72, 89]

2020 Aug 4;32(2):154-175