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and this second mutation must also be sufficiently beneficial to be retained over the 1-Cys variant

One such selenoprotein is glutathione peroxidase (GPx), an important enzyme that uses GSH to detoxify a variety of damaging peroxides and preventing lipid peroxidation in the cell (See Figure 1)

This extensive gene modulation appears to reset gene expression patterns toward healthier, more youthful states

PMID 16537422

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