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Given that cyanide exposure from linamarin is strongly associated with the development of konzo, an increase in plasma oxidative stress may also affect cyanide action or metabolism, potentially amplifying its capacity to induce mitochondrial stress or giving rise to its oxidized form cyanate, which is a strong neurotoxin in various experimental models that can further decrease glutathione levels in the CNS 52,53

159 The current knowledge does rather suggest that AT 2 receptor stimulation will not become another antihypertensive strategy

10.1681/ASN.2011111078 16 BarretoF

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PLoS ONE 11 , e0159524 (2016)