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These effects, observed in animal models, have been linked to improvements in muscle physiology and cardiac performance
Wilmington, R., Ardavani, A., Simenacz, A., Green, C
10.1016/j.heares.2013.01.021 Hear Res
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As shown in Figure 3A, reduced expression levels of IL-6 and 8 and MMP3, 12 and 13 were observed in the FOXO4-DRI treated group, which however were concomitantly accompanied with reduced expression of SOX9 and COL2 , as well as increased expression of CDKN2A, CDKN1A , and TP53 (encoding p53)