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Both require ipamorelin to amplify the GH pulse by overriding somatostatin inhibition

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[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Smith S.B., Maixner D.W., Fillingim R.B., Slade G., Gracely R.H., Ambrose K., Zaykin D.V., Hyde C., John S., Tan K., et al

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A good example of this is given by flutamide, an antiandrogen used in the treatment of prostatic carcinoma, which undergoes substantial metabolism in vivo with hydrolysis of the amide bond liberating 3-trifluoromethyl-4-nitroaniline