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Polyubiquitination of transforming growth factor -activated kinase 1 (TAK1) at lysine 562 residue regulates TLR4-mediated JNK and p38 MAPK activation

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Oral administration in neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and rotenone induced rodent models dose-dependently improved motor function, preserved striatal dopamine and tyrosine hydroxylase levels, and reduced DA neuron loss (Maher, 2021

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A heatmap was made by using the metric fragments per kilobase of feature per million mapped reads (FPKM) value of each transcript, and genes associated with the selected pathways were prominent on the heatmap

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