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Main histological changes of ATN are: merging and loss of tubular epithelial cells, focal dilatation of proximal tubules, partial occlusion of tubular lumens by cellular debris and multiple mitoses

After perforin forms pores in the cell membrane, granzyme B and other proteases enter the target cell and initiate programmed cell death (115)

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A hospital's performance is relative to the performance of all other hospitals in the Hospital VBP Program, and this measure performance scaler methodology is further defined in section V.K.6.b.(3)