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In patients with poorly controlled hypertension (n = 16, age 57 9), 400 mg/d oral BH 4 for 4 weeks significantly improves brachial flow-mediated vasodilation and reduces BP (Porkert et al., 2008)

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a growth hormone-releasing factor analog, is FDA-approved for the treatment of HIV-associated lipodystrophy , with studies showing significant reduction in visceral adipose tissue (VAT) after 26 weeks of useSource: Falutz et al., New England Journal of Medicine, 2010

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