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OS also induces ER stress, activating the UPR and its downstream effector XBP-1, which suppresses insulin receptor expression (Zhang et al., 2025)

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15 The gene for glutathione peroxidase-4 is expressed in most tissues, including the brain (Gene Expression Atlas, available at Although the GPX4 gene is highly polymorphic, a limited number of studies 16, 17, 18, 19 have been done to investigate genetic variations within the GPX4 gene that could potentially alter the function of the enzyme

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Glucagon-like peptide 1-based therapies for type 2 diabetes: a focus on exenatide