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High-dose therapy may also cause a brief increase in blood pressure, though this usually returns to baseline within a few hours

Newborns (especially preterm) lack the ability to metabolize benzyl alcohol, leading to metabolic acidosis, respiratory distress, hypotension and (in reported cases) the often-fatal gasping syndrome. For this reason, only preservative-free sterile water (no benzyl alcohol) is used in pediatric or neonatal care

Healthcare providers need to check each patients health before giving B12 injections, says an expert in obstetrics

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The labeled starting dose is 2.5 mg weekly for at least four weeks

The team built small-molecule NNMT inhibitors on the same chemical family 5-Amino-1MQ belongs to and tested them in diet-induced obese mice on a high-fat diet