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The pathophysiology of PD, limitations of the current treatment strategies, and the major obstacles of its therapies, including the BBB, progressive neurodegeneration, and challenges with targeting specificity are presented

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The risk of MACE was also significantly reduced in consecutive studies (Harmony Outcomes [18], REWIND [19], AMPLITUDE-O [20])

These findings suggest that vitamin D deficiency may act as both a consequence and a mediator of circadian misalignment, potentially compounding the carcinogenic effects of LAN exposure and reinforcing the need to consider vitamin D status in risk stratification and prevention strategies for NSW-exposed individuals 250