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Short-term adverse events include weight gain, moon face, acne, ecchymoses, hypertension, hirsutism, petechial bleeding, striae, and psychosis

Animals were pre-selected into groups to ensure homogeneous performance

Importantly, KRAS-dependent NSCLC cells that were hypersensitive to LDHB/SLC7A11 inhibition (A549, H460, H2122, H838, H2009, KP) exhibited high levels of NRF2 or NRF2 score based on prior studies [57, 58], whereas the outliers (H358, H23, and Calu-1), in which LDHB KD failed to sensitize the cells to Erastin or RSL3, are characterized by low NRF2 levels

It was conducted in full compliance with the Declaration of Helsinki and ICH E6(R2) Good Clinical Practice guidelines

Notably, synovial fibroblasts, osteoblasts, osteoclasts, and immune cells exhibit varying sensitivities to ferroptosis

Kerstetter, J., Kenny, A., Insogna, K