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Key physiological features of the hypothalamo-pituitary-adrenal (HPA) axis are discussed, including the ultradian pulsatility of CRH, AVP and ACTH secretion, the circadian pattern of secretion, the negative feedback of cortisol on the HPA axis, the stress response, and the effects of aging and gender

Nocifensive signs that were used as the behavioral parameters include breathing rate, eye closure, and posture, and these tests were performed at different intervals of time ranging from 15 to 180 min following cystitis

Prepdock website ( and AutoDockTools 1.5.7 software were used for adding hydrogens and symmetry related waters, computing Gasteiger charges, and detecting torsion root 59

Glutathione reductase is another enzyme that helps maintain cellular redox homeostasis by maintaining the supply of reduced glutathione

doi: 10.1038/s41580-021-00418-x 125 JainS

Alzheimer Dis Assoc Disord 2011;25(3):187195