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For skeletal muscle, heart, or corneal models, TB-500 has stronger coverage with several independent teams (Spurney 2010, Bock-Marquette 2004, Sosne 2011)

Long-term safety data for subcutaneous injection is limited

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2016 measured 55.8% wrinkle volume reduction and 32.8% depth reduction over 12 weeks, with a 31.6% greater reduction than Matrixyl 3000 in head-to-head testing

[1] [3] The injections work by bypassing the digestive system entirely, delivering B12 directly into muscle tissue where it can be absorbed into the bloodstream