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, 101 , 458-463, Parks, L

& Collins, S

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Extrinsic Fas-mediated eryptosis A crucial step in the apoptosis mechanism in eukaryotic cells is the activation of caspases, a family of highly conserved cysteine proteases

The failure of their crucial functions has emerged to be one of the important contributing factors of the several CNS disorders situating them to the position of foes. On the other hand, they are able to protect or support neighboring cells, especially during the early phases of ischemia, which marks them as good guys. Thus, defining astrocyte heterogeneity in the healthy, but also ischemic, CNS may enable us to better understand their roles and to support beneficial astrocytes and suppress those damaging the CNS

Levraut M, Cohen M, Bresch S, et al