These include the formation and permeability of the BBB, angiogenesis, CBF, the clearance of toxic cellular metabolites, vascular remodeling, and tone, all of which are essential for the normal functioning of the CNS [39]
For Aging and Longevity: As we age, glutathione levels naturally decline, contributing to increased oxidative stress and cellular damage
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Notably, most of the serum metabolites were negatively correlated with Ileibacterium , Faecalibaculum , Allobaculum , Candidatus Saccharimonas , and Akkermansia , while positive correlations were predominantly observed with Desulfovibrio and Colidextribacter
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A more accurate assessment of these values was not possible due to low solubility of these compounds at high micromolar concentrations