The predicted P eff value for D-NIe-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 (1.53) is intermediate between the predicted P eff values for enalapril (1.25) and piroxicam (2.14), two orally bioavailable drugs
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A multicenter, randomized, double blind, placebo-controlled phase II study of PL 14736 enema in the treatment of mild-to-moderate ulcerative colitis
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It is one of the very few animal peptides to contain a D-amino acid (D-alanine at position 2), an unusual feature that is generated post-translationally by enzymatic conversion of an L-alanine encoded in the gene [2]
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