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Shaking can shear delicate peptide chains and introduce foam

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3F, S3C, D) but not after IgG/ LNP treatment or in healthy animals

Other proposed contributors discussed in the literature include modulation of the dopaminergic and serotonergic systems, growth hormone receptor expression in fibroblasts, and interaction with the nitric oxide system at the level of vasomotor regulation (Sikiric et al., 2018)