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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

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However, you should see your doctor if: You bleed a lot You have symptoms that make it hard to sleep or go about your daily life Your symptoms aren't getting better after about a week of at-home treatment Hemorrhoid Home Remedies To soothe the pain and itching of hemorrhoids, try these tips: Eat more fiber

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