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Ethanol fluidizes the stratum corneum lipid bilayers and improves the deformability of liposomes, facilitating their passage through the intercellular matrix of the stratum corneum to reach viable epidermal layers [258]

Mole Nutrit Food Res Cowana TE, Palmns MSA, Yang J, Bomhof MR, Ardell KL, Reimer RA et al (2014) Chronic coffee consumption in the diet-induced obese rat: impact on gut microbiota and serum metabolomics

This provides preliminary human evidence that the tested formulation reached biologically relevant compartments

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I love the snap close packaging that keeps the formula fresh in-between uses as well

10.1007/978-3-319-99375-1_45 Handbook of immunosenescence