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Blood 46, 253259

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Under normal conditions, pro-inflammatory cytokines (IL-1, IL-6, TNF-) directly stimulate the HPA-axis, resulting in increased glucocorticoid release, which in-turn suppress further pro-inflammatory factor production [140]

After 2 days in vitro (DIV), the cultures were changed to Prenatal Mouse Neuron Media composed of Neurobasal media (Gibco/Fisher Scientific, Cat# 21-103-049) supplemented with B-27 Plus (Fisher Scientific, Cat# A3582801), GlutaMAX Supplement, and penicillin/streptomycin

macrostachyus are safe in mice at 2,000 mg and 5,000 mg/kg, indicating that the extract's LD 50 exceeds 5,000 mg/kg (275)

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