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The Khavinson primate studies are most relevant here: Epitalon increased nighttime melatonin in old monkeys while having no effect on young ones

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Wang L, Liu Y, Zhao TL, Li ZZ, He JY, Zhang BJ, et al

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In type 1 diabetes, mitochondrial ROS production during immune attack amplifies apoptotic signaling, while in type 2 diabetes, chronic metabolic stressors such as hyperglycemia and hyperlipidemia also increase ROS and damage mitochondria in insulin-sensitive tissues

Thus, these beneficial effects are interrelated and appear useful for the therapy of multiple vicious circles that may simultaneously appear in rats permanently maintained under severe intra-abdominal hypertension conditions