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With respect to hypertension, several in vivo studies have provided evidence that eNOS uncoupling occurs in animal models of increased blood pressure, including ATII hypertension, 14 DOCA-salt induced hypertension, 57 NOX1 upregulation 83 and genetically determined hypertension 84 in which an uncoupled eNOS was consistently identified as a significant superoxide source

2023;383:e071725

Detoxifies the body and supports immunity

66 RouhierN.VillarejoA.SrivastavaM.GelhayeE.KeechO.DrouxM.et al (2005)

However, the translation from rodent research to human outcomes is not guaranteed, and no large randomized controlled trials in humans have been published