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Once activated, melanocytes convert the amino acid tyrosine into melanin through a series of enzymatic reactions, primarily involving the enzyme tyrosinase

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Reported results have shown that the addition of pharmacological ascorbate to platinum-based chemotherapy significantly improves tumor deterioration in the advanced stage of NSCLC, by meeting its primary endpoint with an objective response rate of 34.2% and reaching a disease-control rate of 84.2%

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[DOI] [PubMed] [Google Scholar] 9.Baulande S, Lasnier F, Lucas M, Pairault J