This increase at low oxidative stress is due to the stimulation of CBS and GCS that increases GSH synthesis and concentration, and therefore the rate of export
The selective vulnerability of DA neurons in the substantia nigra to ferroptotic damage may be attributed to their high basal oxidative stress, iron-rich environment, and particular lipid composition
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2.1.2 Phenylpropanoids Phenylpropanoids are composed of a benzene ring and a propyl chain and include mainly coniferin and phenylethanol glycosides, which are abundant in Scrophulariae Radix and possess diverse biological activities, such as antioxidation, antitumor, and immunomodulation (27)
Oxidative stress can not only serve as the primary cause of pathology, but also act as the secondary contributor to disease progression
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