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Once inside adipocytes and other metabolically active cells, the compound binds to the NNMT active site, preventing the enzyme from converting nicotinamide to 1-MNA
Studies indicate that long-term metformin use can reduce serum B12 blood test levels by up to 20%, necessitating regular monitoring and preventive B12 supplementation protocols
If your body does not have sufficient B12, then it cannot make energy and so therefore you are weak, tired, or unfocused
These include: Meat Fish Poultry Milk Eggs Fortified breakfast cereals Fortified breads Fortified nutritional yeasts Fortified plant milks If you follow a vegan diet (meaning you don't eat any animal products, including meat, milk, cheese, and eggs) or you're a vegetarian who doesn't eat enough eggs or dairy products, you could be lacking in vitamin B12
Early studies and user feedback suggest a daily dosage of 50mg to 150mg
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