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PubChem Bioassay Record for AID 485364, qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins, Source: National Center for Advancing Translational Sciences (NCATS)

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NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

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For example, miR-434-5p and miR-330-5p are upstream regulators of TYR expression, suggesting that these miRNAs could be used as potential therapeutic targets for pigmentation 40 , 41 , 53