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Most side effects mild (injection site reactions, mild nausea) versus serious complications from less selective pharmaceuticals

then, primary bile acids are metabolized to secondary bile acids by 7-dehydroxylase (Wang et al., 2020)

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This phenomenon, known as metabolic endotoxemia, has been linked to: Chronic inflammation Insulin resistance Obesity Metabolic syndrome In animal studies, even modest increases in circulating endotoxins have been shown to trigger inflammatory responses that interfere with metabolic regulation