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This study shows, in translucent zebrafish, how wound angiogenesis is first inhibited by neutrophils and then driven by VEGF signals from pro-inflammatory macrophages, and finally pruned back again after healing is complete by anti-inflammatory macrophages

Many drug candidates targeting the signalling pathways involved in melanin synthesis have been developed [71, 245]

References Abi-Dargham A, Grace A

It also requires multiple doses throughout the day

Response varies widely, and a clinician should guide what to expect

Melanin is the pigment responsible for the color of our skin, and excessive melanin production can lead to dark spots, uneven skin tone, and blemishes