Furthermore, studies performed in endothelial cells, Kaposis sarcoma-associated herpesvirus (KSHV)-transformed cancer cells and several normal fibroblast or epithelial cell lines reported a similar effect of asparagine on supporting cell survival and protein translation after glutamine deprivation 44,49,50
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The reduction of MYCN protein levels in MYCN-driven brain tumors is of major importance due to its central role as an oncogenic driver (71)
A cascade of cytokines mediates mechanical inflammatory hypernociception in mice
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At the same time, it reduced the expression of interleukin-6 and TNF-alpha, two central inflammatory mediators (Pickart et al., 2015)