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Contraindications and who should approach with caution Patients with active malignancy or a strong personal history of hormonally driven cancers should discuss the telomerase activation mechanism specifically with their provider before beginning Epithalon

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in the Journal of Pharmacology and Experimental Therapeutics (which established Dihexas HGF/c-Met mechanism via Morris water maze rescue with HGF antagonist blockade) was the subject of an Expression of Concern in 2021 and was formally retracted in April 2025 by the publishing journal following investigation into image manipulation