Since creatinine is a byproduct of muscle metabolism, individuals with greater muscle mass, those who engage in more physical activity, or those generally in better health produce more creatinine than people with lower muscle mass, physical activity levels, and poorer overall health
On the other hand, Met plays a critical role in embryonic development and wound healing
Pharmazie 262 ZhuY.DAgostinoJ.ZhangQ
Some patients expand to thighs if abdomen showing too much irritation
Oxford University Press (2015)
H (400 MHz, MeOD): 4.77 (1 H, dd, J = 9.5, 4.4 Hz, H-4), 4.04 (1 H, t, J = 6.3 Hz, H-1), 3.90 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.85 (1 H, d, J = 17.7 Hz, H-6 A or B ), 3.483.36 (4 H, m, PCH 2 + H-7), 3.323.25 (1 H, m, H-5 A or B partially obscured by residual peaks in NMR solvent), 3.243.15 (2 H, m, H-8), 2.95 (1 H, dd, J = 13.9, 9.5 Hz, H-5 A or B ), 2.58 (2 H, t, J = 7.1 Hz, H-3), 2.312.11 (2 H, m, H-2), 1.781.65 (2 H, m, CH 2 ), 1.651.52 (4 H, m, CH 2 )