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It is known that the ability to detoxify APAP varies greatly among different animal species[57]

and disruptions in neurotrophic factors that impair neuronal growth and survival

Everett et al., 2023)

This creates an extraordinarily high binding affinity with pK = 16.44, approximately 10 million times higher than other tripeptides and comparable to albumins copper binding (pK = 16.2)

The compound incorporates N-terminal acetylation and C-terminal amidation , structural modifications commonly applied in peptide chemistry to influence molecular stability and resistance to enzymatic degradation in experimental systems