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A number of approaches targeting deficient GCase activity in GBA-PD have reached the stage of clinical phase 2/3 trials including orally active GCase chaperones to enhance enzymatic activity, substrate reduction therapies modelling current treatment of Gauchers disease and GBA gene therapy (Table 5)
Across these studies, when comparing blood sources measured on a POC device against venous blood with an automated haematology analyser, the 95% limits of agreement (LOA) around the mean were narrower for venous blood (median: 92 g/L, range: 48 to 160 g/L) than for pooled capillary blood (median: 121 g/L, range: 66 to 286 g/L) and single-drop capillary blood (median: 157 g/L, range: 94 to 368 g/L) (appendix p
AI-driven hypoxia imaging using advanced radiomic and deep-learning models applied to MRI, PET, or multiparametric CT scan can non-invasively quantify hypoxic burden, monitor temporal changes during therapy, and guide adaptive treatment strategies (321323)
Lastly, the results of this study consistently indicated the importance of redox potential and nitrogen metabolism to the regulation of hyphal development
Its high protein-binding capacity and preferential accumulation in vaginal tissues make it especially suitable for treating vulvovaginal candidiasis (Schwebke et al., 2022
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