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Lithium has been reported to increase PGC-1 gene expression and mitochondrial biogenesis, and to increase mitochondrial respiration

In contrast, what happens to GABA A and glycine signaling remains controversial: global measurements of the number of inhibitory interneurons, GABA levels, its synthesis enzyme glutamate acid decarboxylase (GAD) or its vesicular transporter (VGAT) as well as GABA A receptors (GABA A Rs) yield contradictory results 8,9,10,11,12,13,14,15,16,17,18

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Excessive combined peptide exposure can overwhelm cellular systems, reducing overall efficacy

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