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The oxidative network itself is complex, with multiple ROS species and redox-sensitive pathways in delicate balance supplementing exogenous antioxidants may unpredictably disrupt signaling, and some agents can even act as pro-oxidants at high concentrations [[154], [155], [156]]

Glutathione S -transferase activity and subunit composition in transitional cell cancer and mucosa of the human bladder

Especially those brought on by oxidative stress, like neurodegenerative diseases [2] which insidiously affect our brain and cognition

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But they are also dose-dependent and temporary