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The concurrent inhibition of MEK (trametinib) and glutamine metabolism (V-9302) enhances antitumor efficacy by orchestrating the FOXO3a/FOXM1 axis and autophagy, leading to pyroptosis and cell cycle arrest (135)
On control plates the biomass of glutathione mutants was not different from the WT, except for zir1 (Fig
doi:10.1038/s41392-021-00791-1 127
Johns Wort (a Western herb) famously induces drug-metabolizing enzymes and can reduce the efficacy of warfarin or statins
C1q/TNF-related protein 5 upregulates 12/15-LOX through STAT6 signaling to accelerate the development of atherosclerosis, while inhibition of 12/15-LOX reduces LDL oxidation and improves atherosclerosis
Food Res Int 51:123131 Pascual O, Vignault A, Gombau J, Navarro M, Gmez-Alonso S, Garca-Romero E, Canals JM, Hermosn-Guterrez I, Teissedre PL, Zamora F (2017) Oxygen consumption rates by different oenological tannins in a model wine solution
