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Each escalation step typically doubles the dose

Supra-additive GH output (Arvat et al., 1997): Hexarelin alone generated a GH AUC of about 2,200.8 256.9 g/Lh and GHRH alone about 792.2 117.6 g/Lh

Schakman O, Kalista S, Bertrand L, Lause P, Verniers J, Ketelslegers JM, Thissen JP (2008) Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats

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