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In addition, the release of damage-associated molecular patterns by tumor cells undergoing ferroptosis also mediates antitumor immunity, and immune therapy can synergize with targeted therapy or radiotherapy through ferroptosis

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At the same time, they showed that localization of L-K6 through clathrin-independent micropinocytosis, without disturbing the cell surface in the cells, causes nuclear damage and cell death, without significant disruption of the cytoskeleton and mitochondrial dysfunction [77]