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Description

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When cells contain fat stores, such as differentiated 3T3-L1 cells (145) as well as HeLa cells grown in oleic acidrich medium (115), desnutrin/ATGL is found both in the cytoplasm and tightly associated with the lipid droplet (115, 130, 145)

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Moreover, phospho-BCL-XL (Ser62) stabilizes G2 arrest by binding to and co-localizing with Cdk1 (cdc2) in nucleolar structures to avoid rapid nucleolar disassembly associated with mitosis onset, playing an unexpected role in the G2 phase checkpoint downstream of DNA damage distinct from its anti-apoptotic function 22

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