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To evaluate the effect of CI inhibition on growth, organoids were seeded as fragments in Matrigel and treated the following day with water (CTRL), 5 M 5FU, 3 mM metformin or a combination of 5FU and metformin for 72 h

& Schwaller, B

Based on clinical trial evidence, the standard cagrilintide starting dose is 0.6 mg weekly , administered subcutaneously

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Common GST polymorphisms include GSTA1, GSTM1, GSTT1, and GSTP1

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