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C-terminal amidation, as seen in Nle-Tyr-Ile-His-NH, also provided a more modest increase in stability

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Other patients also experienced clinical improvements, including a 6 year old boy with severe diabetes, ketosis (accumulation of ketones, a term first used by the German chemist Leopold Gmelin - figure 5), heavy glycosuria and malnutrition (de Levia, Brugus, de Leiva-Prez)