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CSCs are a population of cells within a tumor that possess the ability to self-renew, evade drug action, and reconstitute a heterogenous tumor (39)

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Role of nuclear glutathione as a key regulator of cell proliferation

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Zareba P, Colaci DS, Afeiche M, et al

These stiff gels activate the mechanosensitive ion channel (MIC) TRPV4, which upregulates the activity of the phatidylinositol 3-kinase(PI3k)/Akt pathway, triggering the expression of heat shock protein-(HSP-) 70, which protects against stress-induced cell death [119]