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Oxidants are normal products of the aerobic metabolism that reduces molecular oxygen to water

When cytoplasmic catecholamine concentrations rise to levels that threaten to saturate both VMAT2 sequestration and mitochondrial monoamine oxidase (MAO) degradation pathways, the reversal of plasma membrane transporters provides a vital escape route (Underhill et al., 2021)

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Cell 109 : 383396 Toone WM, Morgan BA and Jones N (2001) Redox control of AP-1-like factors in yeast and beyond